Human chorionic gonadotropin (HCG) is an embryonic hormone that stimulates the release of progesterone to sustain pregnancy. It consists of 237 amino acids having a molecular mass of 25.7kD.
Clinically, HCG is used to treat ovarian disorders and stimulate ovulation in women. In men, it is used to induce testosterone production in patients who are not capable of making testosteronein normal levels. In young boys, HCG is utilized to stimulate the testicle to descend to the scrotum when it has failed to do so by natural means.
Human chorionic gonadotropin (HCG) and the other glycoprotein hormones, namely, luteinizing hormone(LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH),are heterodimers that share a common alpha subunit and possess distinct beta units that are unique to their G protein-linked receptors.As a substance, Human Chorionic Gonadotropin (HCG) is analogous to Luteinizing Hormone(LH). The chemical similarity of hCG to LH results in similar action mechanism in males. Both HCG and LH attach to receptors on human Leydig cells, aprocess that triggers the production and secretion of testosterone.
The parallelism drawn between HCG and LH has made HCG a popular adjunct to performance-enhancing anabolic androgenic steroids (AAS). Injection or introduction of AAS places the body on anegative-feedback mode. Natural regulatory mechanisms respond by shutting down the hypothalamic-pituitary-gonadal axis (HPGA) which leads to stoppage of testosterone production. Testicular deterioration in size and normal functions, among other abnormalities, is one of the side effects of HPGA shutdown.
Elevated quantities of anabolic androgen steroids prompt the hypothalamus to cease producing gonadotropin-releasing hormone (GnRH). In the absence of GnRH, the pituitary gland is unable to release luteinizing hormone (LH). Under ordinary circumstances, the LH would have been released from the pituitary gland to the testes through the bloodstream to trigger the production and secretion of testosterone.The absence of LH prevents the testes from producing testosterone.
HCG is commonly utilized to perform LH functions of prompting normal testosterone production and release as well as maintaining and restoring testicular size during and after steroid cycles. Its association with the use of AAS placed hCG on the list of illicit drugs in several sports. Athletes found guilty of using HCG were suspended or banned temporarily.
Prolonged and excessive dosage that results toelevations intestosterone amounts beyond natural levels would ultimately restrain its own production through negative body feedback mechanisms on the pituitary gland and on the hypothalamus.Should this happen, hCG would have lost its functionality as a substitute for LH.
Among its proponents, there are ongoingdiscussions on what is the optimum frequency in using hCG alongside AAS cycles to ensure maximum benefits. When used in moderation, HCG assists in maintaining normal testicular condition and size.However, it is also speculated that the sporadic use of hCGallows the testicles to remain responsive to LH when the user goes off a steroid cycle.
This may be attributed to HCG’s ability to keep or defenda certain level of Inter-Testicular-Testosterone (ITT) when taken within the cycle. This could help hasten recovery of the hypothalamic-testicular-pituitary-axis. If taken after a cycle, it could still play a part in restoringtesticles back to their normal size and in providing stimulation for the Leydig cells. Other analysts have suggested blending the two schemes of hCG administration in a training regimen.
Side effects of using HCG alone are very rare and hardly serious.Gynecomastia,the development of abnormally large breasts in males, can occur due to heightened levels of the estrogen hormone but it is, nonetheless, uncommon.Combined with anabolic androgenic steroids, hCGhas been known to cause depression, headaches, and edema.
HCG is an embryonic hormone that stimulates the release of progesterone to sustain pregnancy, more details are given at 1hcgdrops.com.